Article
Seasonal changes in brain serotonin transporter binding in short serotonin transporter linked polymorphic region-allele carriers but not in long-allele homozygotes.
Biological psychiatry - 1 Jun 2010
Kalbitzer Jan, Erritzoe David, Holst Klaus K, Nielsen Finn A, Marner Lisbeth, Lehel Szabolcs, Arentzen Tine, Jernigan Terry L, Knudsen Gitte M
Abstract excerpt
BACKGROUND: A polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) has been associated with seasonality both in patients with seasonal affective disorder and in the general population. METHOD: We used in vivo molecular imaging to measure cerebral serotonin transporter (5-HTT) binding in 57 healthy Scandinavians and related the outcome to season of the year and to the 5-HTTLPR carrier...
Topics
- Adult
- Alleles
- Brain
- Brain Mapping
- Female
- Gene Frequency
- Genotype
- Humans
- Image Processing, Computer-Assisted
- Magnetic Resonance Imaging