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Article

Association between seasonal affective disorder and the 5-HT2A promoter polymorphism, -1438G/A.

Molecular psychiatry - 1 Jan 1999

Enoch M A, Goldman D, Barnett R, Sher L, Mazzanti C M, Rosenthal N E

Abstract excerpt

Genes involved in serotonin metabolism are good candidates for the pathogenesis of seasonal affective disorder (SAD). A functional variant in the serotonin transporter promoter, 5-HTTLPR, has recently been shown to be associated with SAD and seasonality. The purpose of this study was to determine...

Topics

Adenine
Adult
Alleles
Carrier Proteins
Female
Gene Frequency
Genetic Variation
Guanine
Humans
Male
Membrane Glycoproteins
Membrane Transport Proteins
Nerve Tissue Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Point Mutation

Polymorphism, Genetic

Promoter Regions, Genetic

Receptor, Serotonin, 5-HT2A

Receptors, Serotonin

Source

Identifiers

PMID: 10089016
DOI: 10.1038/sj.mp.4000439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-10089016-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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