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Article

Synthesis of new thienyl ring containing HIV-1 protease inhibitors: promising preliminary pharmacological evaluation against recombinant HIV-1 proteases.

Journal of medicinal chemistry - 25 Feb 2010

Bonini Carlo, Chiummiento Lucia, De Bonis Margherita, Di Blasio Nadia, Funicello Maria, Lupattelli Paolo, Pandolfo Rocco, Tramutola Francesco, Berti Federico

Abstract excerpt

A series of new thienyl ring containing analogues of nelfinavir and saquinavir with different substitution patterns were synthesized from suitable enantiopure diols. Their inhibitory activity against wild type recombinant HIV-1 protease was evaluated. In general thienyl groups spaced from the cor...

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Identifiers

PMID: 20108932
DOI: 10.1021/jm900846f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20108932-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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