Article
A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2010
Tiwari Arun K, Zai Clement C, Likhodi Olga, Lisker Annika, Singh Deepika, Souza Renan P, Batra Poonam, Zaidi Syed H E, Chen Sheng, Liu Fang, Puls Imke, Meltzer Herbert Y, Lieberman Jeffrey A, Kennedy James L, Müller Daniel J
Abstract excerpt
Antipsychotic-induced weight gain has emerged as a serious complication in the treatment of patients with atypical antipsychotic drugs. The cannabinoid receptor 1 (CNR1) is expressed centrally in the hypothalamic region and associated with appetite and satiety, as well as peripherally. An antagonist of CNR1 (rimonabant) has been effective in causing weight loss in obese patients indicating that CNR1 might be...
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