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Article

Aging, Depot Origin, and Preadipocyte Gene Expression

27 Jan 2010

Abstract excerpt

Fat distribution changes with aging. Inherent changes in fat cell progenitors may contribute because fat cells turn over throughout life. To define mechanisms, gene expression was profiled in preadipocytes cultured from epididymal and perirenal depots of young and old rats. 8.4% of probe sets differed significantly between depots, particularly developmental genes. Only 0.02% differed with aging, despite using...

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PMID: 20106964
DOI: 10.1093/gerona/glp213

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