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Article

Sestrin 2 levels are associated with emphysematous phenotype of COPD.

PloS one - 1 Jan 2022

Angelakis Leonidas, Papaioannou Andriana I, Papathanasiou Evgenia, Mazioti Argiro, Kallieri Maria, Papatheodorou George, Patentalakis George, Hillas Georgios, Papiris Spyridon, Koulouris Nikolaos, Loukides Stelios, Bakakos Petros

Abstract excerpt

Sestrins (Sesns) are a family of highly conserved stress-inducible proteins and various stresses have been shown to strongly up-regulate them. Sestrin 2 (Sesn2) deficiency has been shown to partially suppress pulmonary emphysema. The aim of this study was to evaluate Sesn2 levels in COPD patients and its possible associations with the presence of emphysema and blood eosinophils. All patients underwent lung...

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Source

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Identifiers

PMID: 36040980
DOI: 10.1371/journal.pone.0273652
PMCID: PMC9426901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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