Article
PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.
Cancer research - 1 Feb 2010
Yacoub Adly, Hamed Hossein A, Allegood Jeremy, Mitchell Clint, Spiegel Sarah, Lesniak Maciej S, Ogretmen Besim, Dash Rupesh, Sarkar Devanand, Broaddus William C, Grant Steven, Curiel David T, Fisher Paul B, Dent Paul
Abstract excerpt
Melanoma differentiation associated gene-7(mda-7) encodes IL-24, a cytokine that can selectively trigger apoptosis in transformed cells. Recombinant mda-7 adenovirus (Ad.mda-7) effectively kills glioma cells, offering a novel gene therapy strategy to address deadly brain tumors. In this study, we defined the proximal mechanisms by which Ad-mda-7 kills glioma cells. Key factors implicated included activation of...
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