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Article

A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice.

Developmental biology - 1 Apr 2010

Endoh-Yamagami Setsu, Karkar Kameel M, May Scott R, Cobos Inma, Thwin Myo T, Long Jason E, Ashique Amir M, Zarbalis Konstantinos, Rubenstein John L R, Peterson Andrew S

Abstract excerpt

Precise control of neuronal migration is essential for proper function of the brain. Taking a forward genetic screen, we isolated a mutant mouse with defects in interneuron migration. By genetic mapping, we identified a frame shift mutation in the pericentrin (Pcnt) gene. The Pcnt gene encodes a large centrosomal coiled-coil protein that has been implicated in schizophrenia. Recently, frame shift and premature...

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Source

Identifiers

PMID: 20096683
DOI: 10.1016/j.ydbio.2010.01.017

Genes

PCNT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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