Article
Epigenetic control of cardiomyocyte production in response to a stress during the medaka heart development.
Developmental biology - 1 Apr 2010
Taneda Yusuke, Konno Sayaka, Makino Shinji, Morioka Mai, Fukuda Keiichi, Imai Yoshiyuki, Kudo Akira, Kawakami Atsushi
Abstract excerpt
The size and morphology of organs are largely determined by a genetic program. However in some cases, an epigenetic mechanism influences the process of organ development. Particularly, epigenetic factors such as hemodynamic stress and blood pressure affect the morphogenesis of cardiac chambers and valves. Here, we report that the epigenetic influences affect the cardiomyocyte production. Taking advantage of...
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