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Article

Control of Cardiac Gene Expression by Mechanical Stress

1 Oct 1993

Abstract excerpt

Cardiac growth can be divided into two categories: normal growth in the developmental process and cardiac hypertrophy induced by hemodynamic overload. Since cardiac myocytes are terminally differentiated and lose their ability to duplicate soon after birth, they respond to increased workload only by an increase in cell size (hypertrophy), not by an increase in cell number (hyperplasia). Moreover, the induction of...

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PMID: 8466185
DOI: 10.1146/annurev.ph.55.030193.000415

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