Article
Vitamin D receptor: a new risk marker for clinical restenosis after percutaneous coronary intervention.
Expert opinion on therapeutic targets - 1 Mar 2010
Monraats Pascalle S, Fang Yue, Pons Douwe, Pires Nuno M M, Pols Huibert A P, Zwinderman Aeilko H, de Maat Moniek P M, Doevendans Pieter Af, DeWinter Robbert J, Tio René A, Waltenberger Johannes, Frants Rune R, Quax Paul H A, van der Laarse Arnoud, van der Wall Ernst E, Uitterlinden André G, Jukema J Wouter
Abstract excerpt
OBJECTIVE: Restenosis is the main drawback of percutaneous coronary intervention (PCI). Inherited factors may explain part of the risk of restenosis. Recently, the vitamin D receptor (VDR) has been shown to be involved not only in bone metabolism but also in modulating immune responses and cell proliferation. Since the inflammatory response is implicated in restenosis, VDR-gene variants could therefore contribute...
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