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Article

Mutations affecting DNA-binding activity of the MexR repressor of mexR-mexA-mexB-oprM operon expression.

Journal of bacteriology - 1 Oct 2003

Saito Kohjiro, Akama Hiroyuki, Yoshihara Eisaku, Nakae Taiji

Abstract excerpt

We have isolated 25 MexR mutants that retained their dimerizing ability but were unable to bind mexOP DNA. Surprisingly, 20 mutations were located in the hydrophobic core region at alpha4, W1, alpha2, alpha3, and beta2, and only 3 were in positively charged residues. These results verified that DNA binding is mediated by distinct regions of MexR and showed the importance of the hydrophobic core region of the...

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Identifiers

PMID: 14526032
DOI: 10.1128/JB.185.20.6195-6198.2003
PMCID: PMC225045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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