Article
Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure.
Pigment cell & melanoma research - 1 Apr 2010
Handolias Despina, Salemi Renato, Murray William, Tan Angela, Liu Wendy, Viros Amaya, Dobrovic Alexander, Kelly John, McArthur Grant A
Abstract excerpt
In melanoma, mutations in KIT are most frequent in acral and mucosal subtypes and rarely reported in cutaneous melanomas particularly those associated with intermittent UV exposure. Conversely melanomas arising within chronic sun damaged skin are considered to harbour KIT mutations at higher rates. To characterize the frequency of KIT mutations in a representative melanoma population, 261 patients from two...
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