Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection.

Antimicrobial agents and chemotherapy - 1 Apr 2010

MacCallum Donna M, Coste Alix, Ischer Françoise, Jacobsen Mette D, Odds Frank C, Sanglard Dominique

Abstract excerpt

Principal mechanisms of resistance to azole antifungals include the upregulation of multidrug transporters and the modification of the target enzyme, a cytochrome P450 (Erg11) involved in the 14alpha-demethylation of ergosterol. These mechanisms are often combined in azole-resistant Candida albic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal Agents
Share to Candida albicans
Share to Candidiasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Fungal

Share to Drug Resistance, Fungal

Share to Fluconazole

Share to Genetic Engineering

Share to In Vitro Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 20086148
DOI: 10.1128/AAC.01645-09
PMCID: PMC2849354

Genes

CDR2
TAC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20086148-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection.PMID 20086148Read ↗

Resistance mechanisms in clinical isolates of Candida albicans.Semantic proximity Read ↗

Multidrug Transporters and Alterations in Sterol Biosynthesis Contribute to Azole Antifungal Resistance in Candida parapsilosis.Semantic proximity Read ↗

Stepwise emergence of azole, echinocandin and amphotericin B multidrug resistance in vivo in Candida albicans orchestrated by multiple genetic alterations.Semantic proximity Read ↗

Molecular mechanism of azoles resistant Candida albicans in a patient with chronic mucocutaneous candidiasis.Semantic proximity Read ↗

Genetic and Genomic Architecture of the Evolution of Resistance to Antifungal Drug CombinationsSemantic proximity Read ↗

Distinct roles of Candida albicans drug resistance transcription factors TAC1, MRR1, and UPC2 in virulence.Semantic proximity Read ↗

Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients.Semantic proximity Read ↗

Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.Semantic proximity Read ↗

Rapid, Transient Fluconazole Resistance in <i>Candida albicans</i> Is Associated with Increased mRNA Levels of <i>CDR</i>Semantic proximity Read ↗

Development of Azole Resistance in Aspergillus fumigatus during Azole Therapy Associated with Change in VirulenceSemantic proximity Read ↗

Molecular mechanisms of azole resistance in fungiSemantic proximity Read ↗

Azole Resistance by Loss of Function of the Sterol Δ 5,6 -Desaturase Gene ( ERG3 ) in Candida albicans Does Not Necessarily Decrease VirulenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.