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Article

The N-terminal domain of human holocarboxylase synthetase facilitates biotinylation via direct interaction with the substrate protein.

FEBS letters - 19 Feb 2010

Lee Chung-Kyung, Cheong Chaejoon, Jeon Young Ho

Abstract excerpt

Human holocarboxylase synthetase shows a high degree of sequence homology in the catalytic domain with bacterial biotin ligases such as Escherichia coli BirA, but differs in the length and sequence of the N-terminus. Despite several studies having been undertaken on the N-terminal region of hHCS, the role of this region remains unclear. We determined the structure of the N-terminal domain of hHCS by limited...

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PMID: 20085763
DOI: 10.1016/j.febslet.2009.12.059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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