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Differential DNA Methylation Correlates with Differential Expression of Angiogenic Factors in Human Heart Failure

12 Jan 2010

Abstract excerpt

Epigenetic mechanisms such as microRNA and histone modification are crucially responsible for dysregulated gene expression in heart failure. In contrast, the role of DNA methylation, another well-characterized epigenetic mark, is unknown. In order to examine whether human cardiomyopathy of different etiologies are connected by a unifying pattern of DNA methylation pattern, we undertook profiling with ischaemic...

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PMID: 20084101
DOI: 10.1371/journal.pone.0008564

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