Establishment of a peritoneal mesothelial cell line from a transgenic rat harbouring the temperature-sensitive simian virus 40 large T-antigen gene.

doi:10.1093/ndt/gfp742

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Establishment of a peritoneal mesothelial cell line from a transgenic rat harbouring the temperature-sensitive simian virus 40 large T-antigen gene.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Jun 2010

Hotta Yoko, Kaneko Kayo, Inuma Jiro, Inami Yuko, Aruga Seiki, Shimaoka Tetsutaro, Sekiguchi Yoshimi, Io Hiroaki, Hamada Chieko, Obinata Masuo, Ueda Masatsugu, Tomino Yasuhiko

Abstract excerpt

BACKGROUND: Establishing a peritoneal mesothelial cell (MC) line in which the native characteristics of primary MCs are constantly maintained in vivo is of great significance for investigating their morphological and functional changes in peritoneal dialysis. We established transgenic (Tg) rats that expressed the temperature-sensitive tsA58 mutant of the simian virus 40 large T-antigen (tsSV40T), which served as...

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PMID: 20083474
DOI: 10.1093/ndt/gfp742

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