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Article

Multiple endocrine neoplasia type 2: evaluation of the genotype-phenotype relationship.

Archives of surgery (Chicago, Ill. : 1960) - 1 Apr 2003

Yip Linwah, Cote Gilbert J, Shapiro Suzanne E, Ayers Gregory D, Herzog Cynthia E, Sellin Rena V, Sherman Steven I, Gagel Robert F, Lee Jeffrey E, Evans Douglas B

Abstract excerpt

HYPOTHESIS: Multiple endocrine neoplasia type 2 (MEN 2) is caused by RET proto-oncogene mutations and has a strong penetrance for medullary thyroid carcinoma (MTC). Subtypes are defined by the presence or absence of pheochromocytomas, hyperparathyroidism, and characteristic clinical stigmas. We hypothesize that specific RET mutations correlate with the MEN 2 phenotype and aggressiveness of MTC. DESIGN: Review of...

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PMID: 12686527
DOI: 10.1001/archsurg.138.4.409

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RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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