Article
Influence of the hepatitis C virus 3'-untranslated region on IRES-dependent and cap-dependent translation initiation.
FEBS letters - 19 Feb 2010
Bung C, Bochkaeva Z, Terenin I, Zinovkin R, Shatsky I N, Niepmann M
Abstract excerpt
Translation of hepatitis C virus (HCV) genomic RNA is directed by an internal ribosome entry site (IRES) in the 5'-untranslated region (5'-UTR), and the HCV 3'-UTR enhances IRES activity. Since the HCV 3'-UTR has a unique structure among 3'-UTRs, we checked possible communication between the 5'- and the 3'-UTR of HCV during translation using chimeric reporter RNAs. We show that translation directed by the HCV...
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