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Article

Picornavirus IRESes and the poly(A) tail jointly promote cap-independent translation in a mammalian cell-free system

1 Dec 2000

Abstract excerpt

In eukaryotic cells, efficient translation of most cellular mRNAs requires the synergistic interplay between the m7GpppN cap structure and the poly(A) tail during initiation. We have developed and characterized a cell-free system from human HeLa cells that recapitulates this important feature, displaying more than one order of magnitude of translational synergism between the cap structure and the poly(A) tail....

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PMID: 11142378
DOI: 10.1017/s1355838200001679

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