Article
New evidence for the fetal insulin hypothesis: fetal angiotensinogen M235T polymorphism is associated with birth weight and elevated fetal total glycated hemoglobin at birth.
Journal of hypertension - 1 Apr 2010
Schlemm Ludwig, Haumann Hannah M, Ziegner Maja, Stirnberg Bulza, Sohn Andreas, Alter Markus, Pfab Thiemo, Kalache Karim D, Guthmann Florian, Hocher Berthold
Abstract excerpt
BACKGROUND: Low birth weight is associated with an increased risk of cardiovascular events in later life. Insulin resistance is a key finding in adult patients with cardiovascular diseases. The neonatal phenotype of an individual with insulin resistance might be low birth weight, as insulin influences fetal growth. The renin-angiotensin-aldosterone system has been associated with cardiovascular disease and...
Topics
- Adult
- Angiotensinogen
- Birth Weight
- Female
- Fetal Hemoglobin
- Genotype
- Glycated Hemoglobin
- Humans
- Infant, Newborn
- Insulin
- Mutagenesis, Insertional
- Peptidyl-Dipeptidase A
- Polymorphism, Genetic