Article
Macrophage matrix metalloproteinase-9 mediates epithelial-mesenchymal transition in vitro in murine renal tubular cells.
The American journal of pathology - 1 Mar 2010
Tan Thian Kui, Zheng Guoping, Hsu Tzu-Ting, Wang Ying, Lee Vincent W S, Tian Xinrui, Wang Yiping, Cao Qi, Wang Ya, Harris David C H
Abstract excerpt
As a rich source of pro-fibrogenic growth factors and matrix metalloproteinases (MMPs), macrophages are well-placed to play an important role in renal fibrosis. However, the exact underlying mechanisms and the extent of macrophage involvement are unclear. Tubular cell epithelial-mesenchymal transition (EMT) is an important contributor to renal fibrosis and MMPs to induction of tubular cell EMT. The aim of this...
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