Article
Advances in human immunoglobulin allotypes.
Experimental and clinical immunogenetics - 1 Jan 1995
Grubb R
Abstract excerpt
Monoclonal anti-Rh's and monoclonal anti-Gm's are now available, permitting a more precise serological determination of the human allotypes. Several Gm allotypes can be determined at the gene level, without resort to serological reagents. PCR, subclass-specific amplification and allele-specific probes are used. Many RFLPs of the human IgH C- and V-region genes have now been defined. More than 10(6) variant...
Topics
- Animals
- Chromosomes, Human, Pair 14
- Chromosomes, Human, Pair 2
- Codon
- Disease Susceptibility
- Genes, Immunoglobulin
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Immunoglobulin Allotypes
- Immunoglobulin Heavy Chains
