Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MiR-424-5p regulates cell cycle and inhibits proliferation of hepatocellular carcinoma cells by targeting E2F7

17 Nov 2020

Abstract excerpt

OBJECTIVE: This study aims to explore the mechanism of the miR-424-5p/E2F7 axis in hepatocellular carcinoma (HCC) and provide new ideas for targeted therapy of HCC. METHODS: Bioinformatics analysis was used to identify the target differentially expressed miRNA in HCC and predict its target gene. qRT-PCR was employed to verify the expression of miR-424-5p and E2F7 mRNA in HCC cells. Western blot was performed to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Circular RNAs in diseases
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33201900
DOI: 10.1371/journal.pone.0242179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MiR-424-5p regulates cell cycle and inhibits proliferation of hepatocellular carcinoma cells by targeting E2F7PMID 33201900Read ↗

E2F8 Contributes to Human Hepatocellular Carcinoma via Regulating Cell ProliferationSemantic proximity Read ↗

E2F7 enhances hepatocellular carcinoma growth by preserving the SP1/SOX4/Anillin axis via repressing miRNA‐383‐5p transcriptionSemantic proximity Read ↗

E2F8 is a Potential Therapeutic Target for Hepatocellular CarcinomaSemantic proximity Read ↗

E2F7, regulated by miR‑30c, inhibits apoptosis and promotes cell cycle of prostate cancer cellsSemantic proximity Read ↗

E2F1 and E2F7 regulate gastric cancer cell proliferation, respectively, through transcriptional activation and transcriptional repression of MYBL2Semantic proximity Read ↗

MicroRNA-7 arrests cell cycle in G1 phase by directly targeting CCNE1 in human hepatocellular carcinoma cells.Semantic proximity Read ↗

Effects of Let-7c on the Processing of Hepatitis B Virus Associated Liver DiseasesSemantic proximity Read ↗

MicroRNA-302a/d inhibits the self-renewal capability and cell cycle entry of liver cancer stem cells by targeting the E2F7/AKT axisSemantic proximity Read ↗

E2F8, a direct target of miR-144, promotes papillary thyroid cancer progression via regulating cell cycleSemantic proximity Read ↗

Bromodomain-containing protein 7 (BRD7) as a potential tumor suppressor in hepatocellular carcinomaSemantic proximity Read ↗

ASF1B Serves as a Potential Therapeutic Target by Influencing Cell Cycle and Proliferation in Hepatocellular CarcinomaSemantic proximity Read ↗

MCM7 promotes cancer progression through cyclin D1-dependent signaling and serves as a prognostic marker for patients with hepatocellular carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.