Article
Glutamine synthetase in muscle is required for glutamine production during fasting and extrahepatic ammonia detoxification.
The Journal of biological chemistry - 26 Mar 2010
He Youji, Hakvoort Theodorus B M, Köhler S Eleonore, Vermeulen Jacqueline L M, de Waart D Rudi, de Theije Chiel, Ten Have Gabrie A M, van Eijk Hans M H, Kunne Cindy, Labruyere Wilhelmina T, Houten Sander M, Sokolovic Milka, Ruijter Jan M, Deutz Nicolaas E P, Lamers Wouter H
Abstract excerpt
The main endogenous source of glutamine is de novo synthesis in striated muscle via the enzyme glutamine synthetase (GS). The mice in which GS is selectively but completely eliminated from striated muscle with the Cre-loxP strategy (GS-KO/M mice) are, nevertheless, healthy and fertile. Compared with controls, the circulating concentration and net production of glutamine across the hindquarter were not different...
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