Article

Impaired ureagenesis due to arginine-insensitive N-acetylglutamate synthase

2018-09-25

Abstract excerpt

The urea cycle protects the central nervous system from ammonia toxicity by converting ammonia to non-toxic urea. N-acetylglutamate synthase (NAGS) is an enzyme that catalyzes the formation of N-acetylglutamate (NAG), an allosteric activator of carbamylphosphate synthetase 1 (CPS1), the rate limiting enzyme of the urea cycle. Enzymatic activity of mammalian NAGS doubles in the presence of L-arginine but the physio...

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Literature Corpus work: ad9d9974-aa93-5a04-8c3f-06960fb0fdff
DOI: 10.1101/425959

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