Article
Blasts in transient leukaemia in neonates with Down syndrome differentiate into basophil/mast-cell and megakaryocyte lineages in vitro in association with down-regulation of truncated form of GATA1.
British journal of haematology - 1 Mar 2010
Miyauchi Jun, Ito Yushi, Tsukamoto Keiko, Takahashi Hirotaka, Ishikura Kenji, Sugita Kiyoko, Miyashita Toshiyuki
Abstract excerpt
Mutations of GATA1, leading to aberrant expression of a truncated form of GATA1 (called GATA1s), are present in transient leukaemia (TL) in neonates with Down syndrome. Using these molecular markers of TL, we investigated the growth and differentiation potential of TL blasts in the presence of hematopoietic growth factors (HGFs). Interleukin-3, stem cell factor and granulocyte-macrophage colony-stimulating factor...
Topics
- Basophils
- Cell Differentiation
- Down Syndrome
- Down-Regulation
- Female
- GATA1 Transcription Factor
- Growth Substances
- Humans
- Infant, Newborn
- Leukemia, Megakaryoblastic, Acute
- Male
- Mast Cells
- Megakaryocytes