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Article

MDR1 gene polymorphisms and response to acute risperidone treatment.

Progress in neuro-psychopharmacology & biological psychiatry - 17 Mar 2010

Kastelic Matej, Koprivsek Jure, Plesnicar Blanka Kores, Serretti Alessandro, Mandelli Laura, Locatelli Igor, Grabnar Iztok, Dolzan Vita

Abstract excerpt

Polymorphic multidrug resistant protein 1 (MDR1) transports drugs against a concentration gradient across the blood-brain barrier and reduces their accumulation in the brain. MDR1 may therefore influence antipsychotic brain availability contributing to inter-individual differences in treatment response and adverse effects, regardless of plasma concentrations. In the present study we investigated the influence of...

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PMID: 20060871
DOI: 10.1016/j.pnpbp.2010.01.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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