Article
Genetic and epigenetic influences on expression of spermine synthase and spermine oxidase in suicide completers.
The international journal of neuropsychopharmacology - 1 Jul 2010
Fiori Laura M, Turecki Gustavo
Abstract excerpt
Alterations in the levels of spermine synthase (SMS) and spermine oxidase (SMOX), two enzymes involved in polyamine metabolism, have previously been observed in brains of suicide completers. To characterize the roles played by genetic and epigenetic factors in determining expression levels of these genes, as well as to identify potential mechanisms by which to explain our findings in suicide completers, we (1)...
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