Article
Genetic and epigenetic analysis of SSAT gene dysregulation in suicidal behavior.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Sept 2009
Guipponi Michel, Deutsch Samuel, Kohler Karine, Perroud Nader, Le Gal François, Vessaz Monique, Laforge Térèse, Petit Brice, Jollant Fabrice, Guillaume Sébastien, Baud Patrick, Courtet Philippe, La Harpe Romano, Malafosse Alain
Abstract excerpt
It has recently been proposed that the SSAT gene plays a role in the predisposition to suicidal behavior. SSAT expression was found to be down-regulated in the brain of suicide completers. In addition, a single nucleotide polymorphism (SNP) rs6526342 was associated both with variation in SSAT expression and with suicidal behavior. In this study, we aimed to characterize the relationship between SSAT dysregulation...
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