Article
Allosteric receptors: from electric organ to cognition.
Annual review of pharmacology and toxicology - 1 Jan 2010
Changeux Jean-Pierre
Abstract excerpt
This autobiography covers the past 50 years beginning with the development of the concept of allosteric proteins and its application to pharmacological receptors. It continues with the identification of the nicotinic acetylcholine receptor, the discovery of its molecular organization, the structure of the acetylcholine-binding site and of the ion channel, and the demonstration of its allosteric transitions. The...
Topics
- Allosteric Regulation
- Animals
- Cognition
- Electric Organ
- Epigenesis, Genetic
- Humans
- Ion Channels
- Morphogenesis
- Mutation
- Nicotine
- Receptors, Nicotinic
- Synapses