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Article

Novel brain expression of ClC-1 chloride channels and enrichment of CLCN1 variants in epilepsy.

Neurology - 19 Mar 2013

Chen Tim T, Klassen Tara L, Goldman Alica M, Marini Carla, Guerrini Renzo, Noebels Jeffrey L

Abstract excerpt

OBJECTIVE: To explore the potential contribution of genetic variation in voltage-gated chloride channels to epilepsy, we analyzed CLCN family (CLCN1-7) gene variant profiles in individuals with complex idiopathic epilepsy syndromes and determined the expression of these channels in human and murine brain. METHODS: We used parallel exomic sequencing of 237 ion channel subunit genes to screen individuals with a...

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Source

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Identifiers

PMID: 23408874
DOI: 10.1212/WNL.0b013e31828868e7
PMCID: PMC3662306

Genes

CLCN1
CLCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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