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Article

Mutations in Lama1 disrupt retinal vascular development and inner limiting membrane formation.

The Journal of biological chemistry - 5 Mar 2010

Edwards Malia M, Mammadova-Bach Elmina, Alpy Fabien, Klein Annick, Hicks Wanda L, Roux Michel, Simon-Assmann Patricia, Smith Richard S, Orend Gertraud, Wu Jiang, Peachey Neal S, Naggert Jürgen K, Lefebvre Olivier, Nishina Patsy M

Abstract excerpt

The Neuromutagenesis Facility at the Jackson Laboratory generated a mouse model of retinal vasculopathy, nmf223, which is characterized clinically by vitreal fibroplasia and vessel tortuosity. nmf223 homozygotes also have reduced electroretinogram responses, which are coupled histologically with...

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Source

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Identifiers

PMID: 20048158
DOI: 10.1074/jbc.M109.069575
PMCID: PMC2844215

Genes

LAMA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20048158-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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