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Article

Transgenic expression of the human A20 gene in cloned pigs provides protection against apoptotic and inflammatory stimuli

1 Nov 2009

Abstract excerpt

BACKGROUND: Porcine organs with transgenic expression of anti-apoptotic and anti-inflammatory genes like the human A20 gene (hA20), a tumor necrosis factor-alpha (TNF-alpha)-inducible gene, may control the acute vascular rejection (AVR) of porcine xenografts. The human A20 molecule possesses protective features against inflammatory and apoptotic stimuli in various cell types including endothelial cells, rendering...

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PMID: 20042052
DOI: 10.1111/j.1399-3089.2009.00556.x

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