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Hearts from transgenic pigs constructed with CD59/DAF genomic clones demonstrate improved survival in primates

1 Aug 1999

Abstract excerpt

We have previously created transgenic pigs bearing the human complement regulatory proteins CD59 and decay-accelerating factor (DAF) by either the intercellular transfer or the cDNA transgenic method. To achieve more physiologic protein expression, we constructed a new line of transgenic pigs with CD59 and DAF human genomic clones. We transplanted these CD59/DAF transgenic pig hearts into baboons immunosuppressed...

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PMID: 10503786
DOI: 10.1034/j.1399-3089.1999.00017.x

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