Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pigs transgenic for human thrombomodulin have elevated production of activated protein C

1 Nov 2009

Abstract excerpt

BACKGROUND: The inability of porcine thrombomodulin (TM) to activate human anticoagulant protein C after pig-to-human xenotransplantation may lead to an aberrant activation of coagulation with microthrombosis and ultimately failure of the transplanted organ. Here, we describe the production of triple-transgenic pigs expressing hCD59/DAF and human thrombomodulin (hTM) and tested hTM-transgenic fibroblasts obtained...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Genetics and Reproduction
Share to Pluripotent Stem Cells Research
Share to Xenotransplantation and immune response

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20042048
DOI: 10.1111/j.1399-3089.2009.00537.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pigs transgenic for human thrombomodulin have elevated production of activated protein CPMID 20042048Read ↗

Regulatory Sequences of the Porcine THBD Gene Facilitate Endothelial-Specific Expression of Bioactive Human Thrombomodulin in Single- and Multitransgenic PigsSemantic proximity Read ↗

Production of cloned pigs expressing human thrombomodulin in endothelial cellsSemantic proximity Read ↗

Genetic modification of pigs as organ donors for xenotransplantationSemantic proximity Read ↗

Transgenic Expression of Human Thrombomodulin Inhibits HMGB1-Induced Porcine Aortic Endothelial Cell Activation.Semantic proximity Read ↗

A HUMAN CD46 TRANSGENIC PIG MODEL SYSTEM FOR THE STUDY OF DISCORDANT XENOTRANSPLANTATIONSemantic proximity Read ↗

Selective germline genome edited pigs and their long immune tolerance in Non Human PrimatesSemantic proximity Read ↗

TRANSGENIC PIGS EXPRESSING HUMAN CD59 AND DECAY-ACCELERATING FACTOR PRODUCE AN INTRINSIC BARRIER TO COMPLEMENT-MEDIATED DAMAGE1Semantic proximity Read ↗

Production and Functional Verification of 8‐Gene ( GGTA1 , CMAH , β4GalNT2 , hCD46 , hCD55 , hCD59 , hTBM , hCD39 )‐Edited Donor Pigs for XenotransplantationSemantic proximity Read ↗

Hearts from transgenic pigs constructed with CD59/DAF genomic clones demonstrate improved survival in primatesSemantic proximity Read ↗

Generation of α-1,3-galactosyltransferase knocked-out transgenic cloned pigs with knocked-in five human genesSemantic proximity Read ↗

Evaluation of Physiological Integrity in Six‐Gene‐Edited Bama Miniature Pigs as a Model for XenotransplantationSemantic proximity Read ↗

Transgenic pigs for xenotransplantation: selection of promoter sequences for reliable transgene expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.