Article
Gene expression profiling supports the hypothesis that human ovarian surface epithelia are multipotent and capable of serving as ovarian cancer initiating cells.
BMC medical genomics - 29 Dec 2009
Bowen Nathan J, Walker L DeEtte, Matyunina Lilya V, Logani Sanjay, Totten Kimberly A, Benigno Benedict B, McDonald John F
Abstract excerpt
BACKGROUND: Accumulating evidence suggests that somatic stem cells undergo mutagenic transformation into cancer initiating cells. The serous subtype of ovarian adenocarcinoma in humans has been hypothesized to arise from at least two possible classes of progenitor cells: the ovarian surface epithelia (OSE) and/or an as yet undefined class of progenitor cells residing in the distal end of the fallopian tube....
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