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Article

Association of single nucleotide polymorphisms in CYP1B1 and COMT genes with breast cancer susceptibility in Indian women.

Disease markers - 1 Jan 2009

Yadav Sharawan, Singhal Naveen Kumar, Singh Virendra, Rastogi Neeraj, Srivastava Pramod Kumar, Singh Mahendra Pratap

Abstract excerpt

Cytochrome P450 1B1 (CYP1B1) and catechol-O-methyltransferase (COMT) enzymes play critical roles in estrogen metabolism. Alterations in the catalytic activity of CYP1B1 and COMT enzymes have been found associated with altered breast cancer risk in postmenopausal women in many populations. The substitution of leucine (Leu) to valine (Val) at codon 432 increases the catalytic activity of CYP1B1, however,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catechol O-Methyltransferase

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Share to Polymorphism, Restriction Fragment Length

Source

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Identifiers

PMID: 20037207
DOI: 10.3233/DMA-2009-0663
PMCID: PMC3835283

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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