Article
Migratory behavior of leukemic cells from acute myeloid leukemia patients.
Leukemia - 1 Apr 2002
Voermans C, van Heese W P M, de Jong I, Gerritsen W R, van Der Schoot C E
Abstract excerpt
The chemokine stromal cell-derived factor-1 (SDF-1) and its receptor CXCR-4 contribute to stem cell homing and may play a role in the trafficking of leukemic cells. Therefore, we analyzed migration across Transwell filters of cells derived from bone marrow (BM) or peripheral blood (PB) from 26 acute myeloid leukemia (AML) patients. The presence of the extracellular matrix protein fibronectin (FN) strongly...
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