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BMP4 induction of trophoblast from mouse embryonic stem cells in defined culture conditions on laminin

23 Dec 2009

Abstract excerpt

Because mouse embryonic stem cells (mESCs) do not contribute to the formation of extraembryonic placenta when they are injected into blastocysts, it is believed that mESCs do not differentiate into trophoblast whereas human embryonic stem cells (hESCs) can express trophoblast markers when exposed to bone morphogenetic protein 4 (BMP4) in vitro. To test whether mESCs have the potential to differentiate into...

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PMID: 20033790
DOI: 10.1007/s11626-009-9266-6

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