Article
The effects of sex and method of blood pressure measurement on genetic associations with blood pressure in the PAMELA study.
Journal of hypertension - 1 Mar 2010
Padmanabhan Sandosh, Menni Cristina, Lee Wai K, Laing Stewart, Brambilla Paola, Sega Roberto, Perego Roberto, Grassi Guido, Cesana Giancarlo, Delles Christian, Mancia Giuseppe, Dominiczak Anna F
Abstract excerpt
BACKGROUND: Phenotypic accuracy and specificity are essential for a successful genetic association study. Blood pressure (BP) measurements show heterogeneity depending on the method and time of measurement, sexual dimorphism and measurement errors, making genetic dissection difficult. METHODS AND RESULTS: We studied 1550 adults aged 25-74 years, not on any antihypertensive treatment, resident in Monza, Italy...
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