Article
Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study.
Circulation. Cardiovascular genetics - 1 Feb 2009
Ridker Paul M, Paré Guillaume, Parker Alex N, Zee Robert Y L, Miletich Joseph P, Chasman Daniel I
Abstract excerpt
BACKGROUND: Recent trial data have challenged the hypothesis that cholesteryl ester transfer protein (CETP) and high-density lipoprotein cholesterol (HDL-C) have causal roles in atherothrombosis. One method to evaluate this issue is to examine whether polymorphisms in the CETP gene that impact on HDL-C levels also impact on the future development of myocardial infarction. METHODS AND RESULTS: In a prospective...
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