Article
Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study.
American journal of hematology - 1 Jan 2010
Sebastiani Paola, Solovieff Nadia, Hartley Stephen W, Milton Jacqueline N, Riva Alberto, Dworkis Daniel A, Melista Efthymia, Klings Elizabeth S, Garrett Melanie E, Telen Marilyn J, Ashley-Koch Allison, Baldwin Clinton T, Steinberg Martin H
Abstract excerpt
We conducted a genome-wide association study (GWAS) to discover single nucleotide polymorphisms (SNPs) associated with the severity of sickle cell anemia in 1,265 patients with either "severe" or "mild" disease based on a network model of disease severity. We analyzed data using single SNP analysis and a novel SNP set enrichment analysis (SSEA) developed to discover clusters of associated SNPs. Single SNP...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.