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Article

Activation of WD Repeat and High-Mobility Group Box DNA Binding Protein 1 in Pulmonary and Esophageal Carcinogenesis

22 Dec 2009

Abstract excerpt

PURPOSE: We attempted to identify novel biomarkers and therapeutic targets for lung and esophageal cancers. EXPERIMENTAL DESIGN: We screened for genes that were overexpressed in a large proportion of lung and esophageal carcinomas using a cDNA microarray representing 27,648 genes or expressed sequence tags. A gene encoding WDHD1, a WD repeat and high-mobility group box DNA binding protein 1, was selected as a...

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PMID: 20028748
DOI: 10.1158/1078-0432.ccr-09-1405

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