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Article

Defective retroviruses can disperse in the human genome by intracellular transposition.

Journal of virology - 1 Apr 1991

Tchenio T, Heidmann T

Abstract excerpt

Using an assay for retrotransposition detection (T. Heidmann, O. Heidmann, and J. F. Nicolas, Proc. Natl. Acad. Sci. USA 85:2219-2223, 1988), we demonstrated that a defective retrovirus deleted for the gag, pol, and env open reading frames can disperse in the genome of human HeLa cells by intracellular transposition, at a frequency close to 10(-6) events per cell per generation. Transposition requires cooperation...

Topics

Defective Viruses
Gene Frequency
HeLa Cells
Humans
Mutation
Proviruses
Recombination, Genetic
Retroviridae
Transfection

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2002554
DOI: 10.1128/JVI.65.4.2113-2118.1991
PMCID: PMC240079

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2002554-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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