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Article

The unexpected co-occurrence of GRN and MAPT p.A152T in Basque families: Clinical and pathological characteristics.

PloS one - 1 Jan 2017

Moreno Fermin, Indakoetxea Begoña, Barandiaran Myriam, Caballero María Cristina, Gorostidi Ana, Calafell Francesc, Gabilondo Alazne, Tainta Mikel, Zulaica Miren, Martí Massó José F, López de Munain Adolfo, Sánchez-Juan Pascual, Lee Suzee E

Abstract excerpt

BACKGROUND: The co-occurrence of the c.709-1G>A GRN mutation and the p.A152T MAPT variant has been identified in 18 Basque families affected by frontotemporal dementia (FTD). We aimed to investigate the influence of the p.A152T MAPT variant on the clinical and neuropathological features of these Basque GRN families. METHODS AND FINDINGS: We compared clinical characteristics of 14 patients who carried the...

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Identifiers

PMID: 28594853
DOI: 10.1371/journal.pone.0178093
PMCID: PMC5464560

Genes

GRN
MAPT

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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