Article
A robust error model for iTRAQ quantification reveals divergent signaling between oncogenic FLT3 mutants in acute myeloid leukemia.
Molecular & cellular proteomics : MCP - 1 May 2010
Zhang Yi, Askenazi Manor, Jiang Jingrui, Luckey C John, Griffin James D, Marto Jarrod A
Abstract excerpt
The FLT3 receptor tyrosine kinase plays an important role in normal hematopoietic development and leukemogenesis. Point mutations within the activation loop and in-frame tandem duplications of the juxtamembrane domain represent the most frequent molecular abnormalities observed in acute myeloid leukemia. Interestingly these gain-of-function mutations correlate with different clinical outcomes, suggesting that...
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