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Article

Wild-type FLT3 and FLT3 ITD exhibit similar ligand-induced internalization characteristics.

Journal of cellular and molecular medicine - 1 Apr 2020

Kellner Fabienne, Keil Andreas, Schindler Katrin, Tschongov Todor, Hünninger Kerstin, Loercher Hannah, Rhein Peter, Böhmer Sylvia-Annette, Böhmer Frank-D, Müller Jörg P

Abstract excerpt

Class III receptor tyrosine kinases control the development of hematopoietic stem cells. Constitutive activation of FLT3 by internal tandem duplications (ITD) in the juxtamembrane domain has been causally linked to acute myeloid leukaemia. Oncogenic FLT3 ITD is partially retained in compartments of the biosynthetic route and aberrantly activates STAT5, thereby promoting cellular transformation. The pool of FLT3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32155324
DOI: 10.1111/jcmm.15132
PMCID: PMC7176853

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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