Article
Inhibition of bacterial disulfide bond formation by the anticoagulant warfarin.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jan 2010
Dutton Rachel J, Wayman April, Wei Jun-Rong, Rubin Eric J, Beckwith Jon, Boyd Dana
Abstract excerpt
Blood coagulation in humans requires the activity of vitamin K epoxide reductase (VKOR), the target of the anticoagulant warfarin (Coumadin). Bacterial homologs of VKOR were recently found to participate in a pathway leading to disulfide bond formation in secreted proteins of many bacteria. Here we show that the VKOR homolog from the bacterium Mycobacterium tuberculosis, the causative agent of human tuberculosis,...
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