Article
Stable patterns of gene expression regulating carbohydrate metabolism determined by geographic ancestry.
PloS one - 9 Dec 2009
Schisler Jonathan C, Charles Peter C, Parker Joel S, Hilliard Eleanor G, Mapara Sabeen, Meredith Dane, Lineberger Robert E, Wu Samuel S, Alder Brian D, Stouffer George A, Patterson Cam
Abstract excerpt
BACKGROUND: Individuals of African descent in the United States suffer disproportionately from diseases with a metabolic etiology (obesity, metabolic syndrome, and diabetes), and from the pathological consequences of these disorders (hypertension and cardiovascular disease). METHODOLOGY/PRINCIPAL FINDINGS: Using a combination of genetic/genomic and bioinformatics approaches, we identified a large number of genes...
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